Neurobeachin regulates neurotransmitter receptor trafficking to synapses
نویسندگان
چکیده
منابع مشابه
Neurobeachin regulates neurotransmitter receptor trafficking to synapses
The surface density of neurotransmitter receptors at synapses is a key determinant of synaptic efficacy. Synaptic receptor accumulation is regulated by the transport, postsynaptic anchoring, and turnover of receptors, involving multiple trafficking, sorting, motor, and scaffold proteins. We found that neurons lacking the BEACH (beige-Chediak/Higashi) domain protein Neurobeachin (Nbea) had stron...
متن کاملNeurobeachin regulates transmitter receptor trafficking to synapses
1 Departments of Functional Genomics and Clinical Genetics, Center for Neurogenomics and Cognitive Research, Neuroscience Campus Amsterdam, Vrije Universiteit (VU) and VU Medical Center, 1081 HV Amsterdam, Netherlands 2 Department of Molecular Neurobiology, Max Planck Institute of Experimental Medicine, 37075 Goettingen, Germany 3 Department of Genetics and Medicine, University of Pennsylvania,...
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Vacuolar protein sorting 35 (VPS35) is a core component of the retromer complex, crucial to endosomal protein sorting and intracellular trafficking. We recently linked a mutation in VPS35 (p.D620N) to familial parkinsonism. Here, we characterize human VPS35 and retromer function in mature murine neuronal cultures and investigate neuron-specific consequences of the p.D620N mutation. We find VPS3...
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ژورنال
عنوان ژورنال: The Journal of General Physiology
سال: 2013
ISSN: 0022-1295,1540-7748
DOI: 10.1085/jgp1411oia2